Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells
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چکیده
منابع مشابه
Blood Flow, Blood Oxygen Tension, Oxygen Uptake, and Oxygen Transport in Skeletal Muscle.
STAINSBY, WENDELL N., AND ARTHUR B. OTIS. BZoodLfTow, blood oxygen tension, oxygen uptake, and oxygen transport in skeletal muscle. Am. J. Physiol. 206(4) : 858-866. rg64.-The effect of changes in blood flow and of blood oxygen tension on oxygen uptake of the in situ gastrocnemius-plantaris muscle group of the dog was examined. Oxygen uptake by resting muscle was not altered by changes in blood...
متن کاملPreoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs.
Because of their ability to perfuse remote regions and deliver oxygen, hemoglobin-based oxygen carriers (HBOCs) may be considered in the treatment of several ischemic conditions such as acute coronary syndromes or high-risk percutaneous intervention. Here we studied the effects of intracoronary infusion of ex vivo preoxygenated HBOC-201 during brief total coronary artery occlusion (CAOs) on myo...
متن کاملA hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.
OBJECTIVE To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and cli...
متن کاملA hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation.
BACKGROUND As HBOC-201 improves outcome in animals with hemorrhagic shock (HS), we compared HBOC-201 and HEX (used by U.S. military special operations forces) in a swine model of delayed evacuation and uncontrolled HS. METHODS Twenty-four Yucatan pigs underwent a grade III liver injury and were resuscitated with HBOC-201, HEX, or no fluid (NON). Additional infusions were given for hypotension...
متن کاملRed Cell Stroma and Hemoglobin Metabolism in Anemic Dogs
Red cell stroma protein and hemoglobin can be labeled by feeding C(14) lysine during periods of active blood regeneration following anemia. Stroma proteins are produced and a maximum concentration of the C(14) label appears 2 to 3 days earlier than with hemoglobin,-which is to say that stroma building precedes hemoglobin construction. The concentration of isotope in stroma protein may exceed it...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2003
ISSN: 0741-5214
DOI: 10.1067/mva.2003.127